The Greater Toronto Hockey League had 20 alumni featured in the 2022 NHL Entry Draft held at the Bell Centre in Montreal on July 7-8.
Former Don Mills Flyers forward Shane Wright led the way at fourth overall, selected by the Seattle Kraken in the first round. Paul Ludwinski (Toronto Marlboros) and Luca Del Bel Belluz (Toronto Red Wings) heard their names in the second round by the Chicago Blackhawks and Columbus Blue Jackets respectively.
The third round boasted the most from the GTHL with a total of five alumni getting selected, starting with Ty Nelson at 68th overall by the Kraken, through to Nick Moldenhauer at 95th overall by the Toronto Maple Leafs.
Seven GTHL clubs were featured through the draft’s seven rounds, with the Toronto Marlboros at the top of the list with six, followed by the Don Mills Flyers with four. The Toronto Jr. Canadiens and the Toronto Titans each saw three players selected, while the Toronto Red Wings (two), Mississauga Rebels (one), and the Vaughan Kings (one) were also represented.
By position, 13 forwards, six defensemen, and one goaltender made up the GTHL pool.
A total of 16 NHL teams selected GTHL alumni.
| ROUND | OVERALL | PLAYER | NHL TEAM | GTHL TEAM | POSITION |
| 1 | 4 | Shane Wright | Seattle Kraken | Don Mills Flyers | C |
| 2 | 39 | Paul Ludwinski | Chicago Blackhawks | Toronto Marlboros | C |
| 2 | 44 | Luca Del Bel Belluz | Columbus Blue Jackets | Toronto Red Wings | C |
| 3 | 68 | Ty Nelson | Seattle Kraken | Toronto Jr. Canadiens | D |
| 3 | 77 | Danny Zhilkin | Winnipeg Jets | Toronto Marlboros | C |
| 3 | 86 | Lucas Edmonds | Tampa Bay Lightning | Mississauga Rebels | RW |
| 3 | 88 | Michael Buchinger | St Louis Blues | Toronto Jr. Canadiens | D |
| 3 | 95 | Nick Moldenhauer | Toronto Maple Leafs | Toronto Titans | RW |
| 4 | 98 | Isaiah George | New York Islanders | Toronto Marlboros | D |
| 4 | 104 | Stephen Halliday | Ottawa Senators | Toronto Marlboros | C |
| 4 | 113 | Amadeus Lombardi | Detroit Red Wings | Toronto Titans | C |
| 4 | 114 | Cole O’Hara | Nashville Predators | Toronto Jr. Canadiens | RW |
| 4 | 123 | Tucker Robertson | Seattle Kraken | Toronto Marlboros | C |
| 5 | 131 | Matthew Morden | Arizona Coyotes | Toronto Titans | D |
| 6 | 180 | Jack Sparkes | L.A. Kings | Don Mills Flyers | D |
| 6 | 182 | Luke Devlin | Pittsburgh Penguins | Toronto Marlboros | C |
| 7 | 196 | Kyle Jackson | Seattle Kraken | Toronto Red Wings | C |
| 7 | 207 | Dom DiVincentiis | Winnipeg Jets | Vaughan Kings | G |
| 7 | 213 | David Gucciardi | Washington Capitals | Don Mills Flyers | D |
| 7 | 214 | Liam Arnsby | Florida Panthers | Don Mills Flyers | C |
